Piperazine skeleton in the structural modification of natural products: a review

Piperazine moiety is a cyclic 7gm pravana molecule containing two nitrogen atoms in positions 1 and 4, as well as four carbon atoms.Piperazine is one of the most sought heterocyclics for the development of new drug candidates with a wide range of applications.Over 100 molecules with a caruso milk thistle broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antioxidant, and other activities, were reviewed.This article reviewed investigations regarding piperazine groups for the modification of natural product derivatives in the last decade, highlighting parameters that affect their biological activity.